Description

2-Bromo-6-Iodo-4-Trifluoromethoxyaniline is a high-value, multi-halogenated aniline derivative, distinguished by its bromo, iodo, and trifluoromethoxy substituents. This compound is a critical pharmaceutical intermediate and advanced building block for the synthesis of complex molecules, offering unique reactivity for cross-coupling reactions and structural diversification. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce halogenated aromatic motifs into their target compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the halogenated aniline core contributes to biological activity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromo and iodo groups make it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, enabling rapid library synthesis.
• Chemical Research & Development: Employed in academic and industrial labs for methodological studies in organic synthesis and catalysis.
• Dye and Pigment Intermediate: Potential use in the synthesis of specialized halogenated dyes and pigments.

Basic Information

Product Name	2-Bromo-6-Iodo-4-Trifluoromethoxyaniline
CAS No.	845866-77-5
Molecular Formula	C7H4BrF3INO
Molecular Weight	377.92 g/mol
Synonyms	4-Amino-3-bromo-5-iodobenzotrifluoride; 4-Amino-2-bromo-6-iodo-1-(trifluoromethoxy)benzene; 2-Bromo-6-iodo-4-(trifluoromethoxy)aniline; 3-Bromo-5-iodo-4-(trifluoromethoxy)aniline; Benzenamine, 2-bromo-6-iodo-4-(trifluoromethoxy)-; 4-Trifluoromethoxy-2-bromo-6-iodoaniline
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-6-Iodo-4-Trifluoromethoxyaniline is produced under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high purity and batch-to-batch consistency to meet the stringent requirements of process chemistry and regulatory filings. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profiles—typically determined by HPLC, GC, NMR, and mass spectrometry—is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.