Description

4'-Chloro-2,2,2,3'-Tetrafluoroacetophenone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity profile imparted by the strategic placement of chlorine and fluorine substituents on the acetophenone core, enabling precise molecular modifications. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorinated aromatic structure contributes to efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials, contributing to desired dielectric and optical properties.
• Advanced Polymer Chemistry: Employed as a monomer or cross-linking agent in the creation of specialty polymers with specific thermal and chemical resistance.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, nucleophilic substitutions, and as a precursor for heterocyclic compounds in various fine chemical applications.

Basic Information

Item	Detail
Product Name	4'-Chloro-2,2,2,3'-Tetrafluoroacetophenone
CAS No.	845823-15-6
Molecular Formula	C8H3ClF4O
Molecular Weight	226.56 g/mol
Synonyms	1-(4-Chloro-3-fluorophenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(4-chloro-3-fluorophenyl)ethanone; 4-Chloro-3-fluoro-α,α,α-trifluoroacetophenone; 4'-Chloro-3'-fluoro-2,2,2-trifluoroacetophenone; p-Chloro-m-fluoro-α,α,α-trifluoroacetophenone; 845823-15-6; 4-Chloro-3-fluorophenyl trifluoromethyl ketone
EINECS	Contact for details

Quality Control

Our 4'-Chloro-2,2,2,3'-Tetrafluoroacetophenone is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and scale-up activities. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.