Description

5-Chloro-2-Trifluoromethyl-Pyrimidine is a high-value halogenated pyrimidine building block, distinguished by its trifluoromethyl and chloro substituents which impart unique electronic and steric properties. This compound is essential for medicinal chemistry and agrochemical research, enabling the synthesis of novel molecules with enhanced biological activity and metabolic stability. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers developing active ingredients for drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the stability of the CF3 group.
• Material Science Research: Serves as a precursor for functionalized materials, including liquid crystals and organic electronic components.
• Cross-Coupling Reactions: Acts as a versatile substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Fluorine Chemistry Building Block: Integral for introducing fluorine atoms into target molecules to fine-tune lipophilicity, bioavailability, and binding affinity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up.

Basic Information

Product Name	5-Chloro-2-Trifluoromethyl-Pyrimidine
CAS No.	845618-08-8
Molecular Formula	C5H2ClF3N2
Molecular Weight	182.53 g/mol
Synonyms	2-(Trifluoromethyl)-5-chloropyrimidine; 5-Chloro-2-(trifluoromethyl)pyrimidine; Pyrimidine, 5-chloro-2-(trifluoromethyl)-; 5-Chloro-α,α,α-trifluoro-2-pyrimidinemethane
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-2-Trifluoromethyl-Pyrimidine is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, GC, and NMR analysis, to ensure high purity and consistency that meets the stringent requirements of research and production applications. Certificates of Analysis (COA) with full analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.