Description

3-Chloro-4,4'-Difluorobenzhydrol is a high-purity fluorinated benzhydrol derivative, serving as a critical advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its unique structure, featuring both chloro and fluoro substituents, makes it invaluable for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, where the difluoro motif enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving performance and durability.
• Polymer Chemistry: Acts as a monomer or chain modifier for creating specialty polymers with tailored thermal and chemical resistance properties.
• Cross-Coupling Reactions: An effective substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Ligand & Catalyst Development: Utilized in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	3-Chloro-4,4'-Difluorobenzhydrol
CAS No.	844683-73-4
Molecular Formula	C13H9ClF2O
Molecular Weight	254.66 g/mol
Synonyms	(3-Chloro-4-fluorophenyl)(4-fluorophenyl)methanol; 1-(3-Chloro-4-fluorophenyl)-1-(4-fluorophenyl)methanol; α-(3-Chloro-4-fluorophenyl)-4-fluorobenzyl alcohol; 3-Chloro-α,α'-difluorobenzhydrol; Benzhydrol, 3-chloro-4,4'-difluoro-; 844683-73-4; 3-Chloro-4,4'-difluorodiphenylmethanol
EINECS	Contact for details

Quality Control

Our 3-Chloro-4,4'-Difluorobenzhydrol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.