Description

4-Chloro-3',5'-Difluorobenzhydrol is a high-purity fluorinated benzhydrol derivative, serving as a critical advanced pharmaceutical intermediate (API) and versatile building block in organic synthesis. Its value lies in its unique molecular structure, which enables the precise introduction of chloro and difluoro substituents into complex target molecules, a key step in developing compounds with enhanced biological activity and metabolic stability. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating new active ingredients and fine-tuning the properties of existing ones.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Liquid Crystal Material Precursor: Serves as a starting material for synthesizing fluorinated liquid crystal compounds used in display technologies.
• Organic Light-Emitting Diode (OLED) Materials: Acts as an intermediate in the development of electron-transport or host materials for OLED devices.
• Cross-Coupling Reactions: Utilized in Suzuki, Stille, or other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Research & Development: Employed in academic and industrial R&D labs as a versatile scaffold for medicinal chemistry and material science explorations.

Basic Information

Product Name	4-Chloro-3',5'-Difluorobenzhydrol
CAS No.	844683-38-1
Molecular Formula	C13H9ClF2O
Molecular Weight	254.66 g/mol
Synonyms	(4-Chlorophenyl)(3,5-difluorophenyl)methanol; Benzhydrol, 4-chloro-3',5'-difluoro-; 3,5-Difluoro-4'-chlorobenzhydrol; α-(4-Chlorophenyl)-3,5-difluorobenzyl alcohol; (3,5-Difluorophenyl)(4-chlorophenyl)methanol
EINECS	Contact for details

Quality Control

Our 4-Chloro-3',5'-Difluorobenzhydrol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.