Description

(Cys8)-Pth (1-8) (Human) CAS NO 844499-32-7 is a synthetic peptide fragment corresponding to the N-terminal region of human parathyroid hormone. This compound is a critical research tool for studying calcium metabolism, bone biology, and endocrine signaling pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in metabolic disorder research and peptide-based drug discovery.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of parathyroid hormone (PTH) receptor binding and activation mechanisms.
• Drug Discovery: Serves as a key intermediate or pharmacophore model in the development of novel therapeutics for osteoporosis and hyperparathyroidism.
• Diagnostic Development: Employed in the development and calibration of immunoassays (e.g., ELISA) for the detection and quantification of PTH-related peptides.
• Cell Signaling Studies: Applied in vitro to investigate the downstream effects of PTH fragment stimulation on osteoblast and osteoclast activity.
• Peptide Chemistry: Used as a building block or model compound in methodological studies of peptide synthesis, modification, and stability.

Basic Information

Product Name	(Cys8)-Pth (1-8) (Human)
CAS No.	844499-32-7
Molecular Formula	C42H68N14O12S2
Molecular Weight	1001.2 g/mol
Synonyms	PTH (1-8) (Human) Cys8 analog; [Cys8]-Parathyroid Hormone (1-8); H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Cys-OH; [Cys8]hPTH(1-8); Parathyroid hormone fragment 1-8 (human, cysteine8); Cys8-PTH(1-8); PTH (1-8) amide (human) Cys8 variant
EINECS	Contact for details

Quality Control

Our (Cys8)-Pth (1-8) (Human) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and MS for identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular ion peak consistent with theoretical mass
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.