Description

(S)-Cyclopropyl(2-Fluorophenyl)Methanamine Hydrochloride is a high-purity chiral amine building block essential for advanced pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is primarily utilized by medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries for creating novel therapeutic candidates.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of new drug candidates, especially in neuropharmacology.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the construction of complex molecules for preclinical and clinical studies.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization due to its defined stereochemistry and fluorinated aromatic ring.
• Process Chemistry & Scale-Up: Serves as a starting material or intermediate in the development of robust, scalable synthetic routes for GMP manufacturing.
• Asymmetric Synthesis: Employed in chiral pool synthesis or as a resolving agent for creating enantiomerically pure compounds.
• Reference Standard: Used as an analytical standard for quality control and regulatory filings (e.g., FDA, EMA).

Basic Information

Product Name	(S)-Cyclopropyl(2-Fluorophenyl)Methanamine Hydrochloride
CAS No.	844470-82-2
Molecular Formula	C10H13FN • HCl
Molecular Weight	201.68 g/mol (Free base: 165.22 g/mol)
Synonyms	(1S)-1-Cyclopropyl-1-(2-fluorophenyl)methanamine hydrochloride; (S)-1-(2-Fluorophenyl)-1-cyclopropylmethanamine HCl; (S)-α-(2-Fluorophenyl)cyclopropanemethylamine hydrochloride; (S)-2-Fluoro-α-(cyclopropylmethyl)benzenemethanamine hydrochloride; (S)-CPFMA HCl; (S)-Cyclopropyl(2-fluorophenyl)methylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Cyclopropyl(2-Fluorophenyl)Methanamine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.