Description

L-Glutamic Acid, n-[16-(1,1-Dimethylethoxy)-1,16-Dioxohexadecyl]-, 1-(1,1-Dimethylethyl) Ester is a sophisticated, high-purity synthetic derivative of glutamic acid, designed for advanced research and development applications. This compound matters as a key protected intermediate, offering precise chemical functionality for the synthesis of complex peptides, bioactive conjugates, and novel materials. It is primarily needed by pharmaceutical R&D teams, bioconjugation specialists, and advanced material scientists working on targeted drug delivery systems, diagnostic probes, and specialty polymers.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel peptide-based therapeutics and targeted drug conjugates.
• Bioconjugation Chemistry: Used for the site-specific modification of proteins, antibodies, or other biomolecules to create advanced diagnostic or therapeutic agents.
• Advanced Material Synthesis: Acts as a functional monomer or cross-linker in the development of smart polymers, hydrogels, and biodegradable materials.
• Proteomics & Biochemical Research: Employed as a tool compound in studying enzyme mechanisms, protein-protein interactions, and cellular signaling pathways.
• Peptide Library Construction: Facilitates the solid-phase or solution-phase synthesis of custom peptide sequences for screening and discovery.
• Linker Technology: Functions as a cleavable or stable linker in prodrug design and controlled-release formulations.

Basic Information

Product Name	L-Glutamic Acid, n-[16-(1,1-Dimethylethoxy)-1,16-Dioxohexadecyl]-, 1-(1,1-Dimethyl) Ester
CAS No.	843666-29-5
Molecular Formula	C29H53NO6
Molecular Weight	511.74 g/mol
Synonyms	tert-Butyl N-[16-(tert-butoxy)-1,16-dioxohexadecyl]-L-glutamate; L-Glutamic acid, N-[16-(1,1-dimethylethoxy)-1,16-dioxohexadecyl]-, 1-(1,1-dimethylethyl) ester; Boc-Glu(OtBu)-OH extended chain derivative; N-(16-tert-Butoxy-1,16-dioxohexadecyl)-L-glutamic acid 1-tert-butyl ester; Protected glutamic acid C16 derivative; Glutamate-based long-chain di-tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chemical purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is moisture-sensitive; containers should be allowed to equilibrate to room temperature before opening to prevent condensation. Store in a cool, dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.