Description

1-(4-Bromo-Phenyl)-2,2,2-Trifluoro-Ethylamine is a high-purity, specialized aromatic amine building block featuring both bromine and trifluoromethyl substituents. This compound is valued for its unique molecular architecture, which enables precise structural modifications in advanced chemical synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the biological activity imparted by the halogen and fluorine groups.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and transition metal complexes.
• Material Science Precursor: Employed in the research and development of advanced polymers, liquid crystals, and organic electronic materials.
• Fluorine Chemistry Building Block: Essential for introducing the trifluoroethylamine moiety into target molecules to alter physicochemical properties like metabolic stability and lipophilicity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	1-(4-Bromo-Phenyl)-2,2,2-Trifluoro-Ethylamine
CAS No.	843608-46-8
Molecular Formula	C8H7BrF3N
Molecular Weight	254.05 g/mol
Synonyms	4-Bromo-α-(trifluoromethyl)benzylamine; 1-(4-Bromophenyl)-2,2,2-trifluoroethanamine; 4-Bromo-α,α,α-trifluoroethylbenzylamine; (4-Bromophenyl)(trifluoromethyl)methylamine; p-Bromo-α-(trifluoromethyl)benzylamine; 2,2,2-Trifluoro-1-(4-bromophenyl)ethanamine; 1-(4-Bromophenyl)-2,2,2-trifluoroethylamine; 4'-Bromo-α,α,α-trifluoroacetophenone imine (reduction product)
EINECS	Contact for details

Quality Control

Every batch of 1-(4-Bromo-Phenyl)-2,2,2-Trifluoro-Ethylamine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) including purity (HPLC/GC), identity confirmation (IR, NMR), and impurity profile is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.