Description

Fmoc-3,3-Diphenyl-Dl-Alanine CAS NO 839719-72-1 is a protected, non-natural amino acid derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). Its value lies in the unique steric and aromatic properties imparted by the diphenyl group at the β-carbon, which is essential for constructing peptides with specific conformational constraints or enhanced stability. This compound is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of custom peptide chains, particularly those requiring bulky, non-proteinogenic amino acids.
• Pharmaceutical Research: Incorporation into novel peptide-based drug candidates to modulate bioactivity, improve metabolic stability, or alter receptor binding affinity.
• Peptidomimetic Design: Serves as a scaffold for creating molecules that mimic the structure and function of natural peptides but with improved pharmacological properties.
• Bioconjugation and Probe Development: Used to introduce the Fmoc-protected diphenylalanine moiety into larger biomolecules or fluorescent tags for biochemical studies.
• Combinatorial Chemistry Libraries: A valuable building block for generating diverse libraries of compounds for high-throughput screening in drug discovery.
• Academic & Industrial R&D: Fundamental research tool in organic chemistry, medicinal chemistry, and chemical biology for studying peptide structure-activity relationships.

Basic Information

Product Name	Fmoc-3,3-Diphenyl-Dl-Alanine
CAS No.	839719-72-1
Molecular Formula	C30H25NO4
Molecular Weight	463.52 g/mol
Synonyms	Fmoc-Diphenylalanine; Fmoc-3,3-Diphenylalanine; N-(9-Fluorenylmethoxycarbonyl)-3,3-diphenyl-DL-alanine; (RS)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,3-diphenylpropanoic acid; Fmoc-DL-3,3-Diphenyl-Ala-OH; Fmoc-β,β-Diphenyl-DL-alanine; N-Fmoc-3,3-diphenyl-DL-alanine; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3,3-diphenylpropanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-3,3-Diphenyl-Dl-Alanine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and chiral analysis to verify the DL-mixture. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications to ensure compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.