Description

4-(6-Acetyl-1,3,7-Trimethyl-2,4-Dioxo-1,2,3,4,5,8-Hexahydropyrido[2,3-D]Pyrimidin-5-Yl)Benzonitrile is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in the fields of oncology and targeted drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, especially kinase inhibitors and other targeted small molecules.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic entities.
• Process Chemistry Development: Employed in scaling up synthetic routes and optimizing manufacturing processes for active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for investigating novel heterocyclic chemistry and biological activity.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control.

Basic Information

Product Name	4-(6-Acetyl-1,3,7-Trimethyl-2,4-Dioxo-1,2,3,4,5,8-Hexahydropyrido[2,3-D]Pyrimidin-5-Yl)Benzonitrile
CAS No.	838845-73-1
Molecular Formula	C21H18N4O3
Molecular Weight	374.40 g/mol
Synonyms	4-(6-Acetyl-1,3,7-trimethyl-2,4-dioxo-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)benzonitrile; 5-(4-Cyanophenyl)-1,3,7-trimethyl-6-acetyl-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-2,4-dione; CAS 838845-73-1; Pyrido[2,3-d]pyrimidine derivative; 5-(4-Cyanophenyl)hexahydropyrido[2,3-d]pyrimidinedione
EINECS	Contact for details

Quality Control

Our 4-(6-Acetyl-1,3,7-Trimethyl-2,4-Dioxo-1,2,3,4,5,8-Hexahydropyrido[2,3-D]Pyrimidin-5-Yl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.