Description

Phenol, 3-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of targeted kinase inhibitors. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel active pharmaceutical ingredients (APIs). The material's specific molecular architecture makes it a valuable building block for creating potent and selective therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of targeted kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used as a core scaffold in drug discovery programs for structure-activity relationship (SAR) studies.
• Biochemical Tool Compound: Serves as a starting material for developing labeled probes or analogs used in biochemical and cellular assays.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing of complex, high-value specialty chemicals.
• API Development: Integral to the process development and scale-up of new active pharmaceutical ingredients under GMP conditions.

Basic Information

Product Name	Phenol, 3-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-
CAS No.	833481-69-9
Molecular Formula	C14H15N5O
Molecular Weight	269.30 g/mol
Synonyms	3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol; 1-Isopropyl-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 4-Amino-1-isopropyl-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine; 833481-69-9; Phenol, 3-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]- (9CI); 3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support development under quality agreements and can align with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.