Description

2-(Difluoromethoxy)-4-Fluoroaniline is a specialized fluorinated aniline derivative, serving as a critical building block in advanced organic synthesis. Its unique difluoromethoxy and fluoro substituents make it a valuable intermediate for creating compounds with enhanced metabolic stability and bioavailability. This high-purity intermediate is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing active ingredients and agrochemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the difluoromethoxy group can improve lipophilicity and biological activity.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in advanced display technologies.
• Polymer Chemistry: Intermediate for synthesizing specialty monomers and polymers with specific fluorine-related properties like chemical resistance and low surface energy.
• Organic Electronics: Used in the research and development of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Research & Development: A versatile reagent for introducing the 2-(difluoromethoxy)-4-fluoroaniline moiety into more complex molecular architectures in academic and industrial labs.

Basic Information

Item	Details
Product Name	2-(Difluoromethoxy)-4-Fluoroaniline
CAS No.	832740-98-4
Molecular Formula	C7H6F3NO
Molecular Weight	177.12 g/mol
Synonyms	4-Fluoro-2-(difluoromethoxy)aniline; 2-(Difluoromethoxy)-4-fluoro-benzenamine; 4-Fluoro-2-(difluoromethoxy)phenylamine; 1-Amino-4-fluoro-2-(difluoromethoxy)benzene; Benzenamine, 4-fluoro-2-(difluoromethoxy)-; 832740-98-4; 2-(Difluoromethoxy)-4-fluoroaniline
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)-4-Fluoroaniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request. Our production adheres to cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong oxidizing agents and acids. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.