Description

Ethyl 5-Cyclopropyl-7-(Difluoromethyl)-4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrimidine-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of proprietary drug candidates, especially those targeting kinase inhibition.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs for scale-up and cGMP production of clinical trial materials and commercial APIs.
• Agrochemical Research: Potential application as an intermediate in the development of new crop protection agents, leveraging its pyrazolopyrimidine core.
• Chemical Biology Probes: Can be utilized to create tool compounds for investigating biological pathways and target validation in academic and industrial research.

Basic Information

Product Name	Ethyl 5-Cyclopropyl-7-(Difluoromethyl)-4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrimidine-3-Carboxylate
CAS No.	832740-92-8
Molecular Formula	C13H15F2N3O2
Molecular Weight	283.28 g/mol
Synonyms	Ethyl 5-cyclopropyl-7-(difluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate; 832740-92-8; 5-Cyclopropyl-7-(difluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester; SCHEMBL23383077; AKOS040759425; ZINC000095909991; A1-00826; 4,5,6,7-Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 5-cyclopropyl-7-(difluoromethyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl 5-Cyclopropyl-7-(Difluoromethyl)-4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrimidine-3-Carboxylate is produced and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.