Description

5-Cyclopropyl-7-Difluoromethyl-Pyrazolo[1,5-A]Pyrimidine-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its pyrazolopyrimidine core, a privileged scaffold in medicinal chemistry. This compound is of significant commercial value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting kinase inhibition. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of next-generation therapeutics for oncology and inflammatory diseases.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities.
• Active Pharmaceutical Ingredient (API) Synthesis: Incorporated into the final molecular structure of target APIs, leveraging its difluoromethyl and carboxylic acid functional groups for further derivatization.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs for scale-up and cGMP production of clinical trial materials and commercial drug substances.
• Biochemical Tool Compound: Potential use in biochemical assays to study specific enzyme interactions and pathways.

Basic Information

Product Name	5-Cyclopropyl-7-Difluoromethyl-Pyrazolo[1,5-A]Pyrimidine-2-Carboxylic Acid
CAS No.	832739-74-9
Molecular Formula	C₁₂H₉F₂N₃O₂
Molecular Weight	265.22 g/mol
Synonyms	5-Cyclopropyl-7-(difluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid; 7-(Difluoromethyl)-5-cyclopropylpyrazolo[1,5-a]pyrimidine-2-carboxylic Acid; Pyrazolo[1,5-a]pyrimidine-2-carboxylic acid, 5-cyclopropyl-7-(difluoromethyl)-; 832739-74-9; 5-Cyclopropyl-7-difluoromethyl-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid; 5-Cyclopropyl-7-(difluoromethyl)-1H-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 5-Cyclopropyl-7-Difluoromethyl-Pyrazolo[1,5-A]Pyrimidine-2-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to fluoride/strong alkali; keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.