Description

2-(Difluoromethoxy)-5-Methylaniline is a specialized aromatic amine derivative featuring a difluoromethoxy substituent, which imparts unique electronic and steric properties critical for advanced chemical synthesis. This compound serves as a high-value pharmaceutical intermediate and agrochemical building block, enabling the development of novel active ingredients with enhanced efficacy and stability. It is primarily utilized by R&D chemists and process development scientists in the life sciences and crop protection industries seeking to incorporate fluorine chemistry into their molecular designs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Synthesis: Serves as a crucial building block for developing new-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve metabolic stability and bioavailability.
• Material Science Research: Used in the development of advanced polymers, liquid crystals, and organic electronic materials due to its aromatic amine functionality and fluorine content.
• Dye and Pigment Intermediate: Acts as a starting material for synthesizing specialized azo dyes and pigments requiring specific light-fastness and chemical resistance properties.
• Cross-Coupling Reactions: An important substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) for constructing complex nitrogen-containing heterocycles.

Basic Information

Product Name	2-(Difluoromethoxy)-5-Methylaniline
CAS No.	832739-40-9
Molecular Formula	C8H9F2NO
Molecular Weight	173.16 g/mol
Synonyms	5-Methyl-2-(difluoromethoxy)aniline; 2-Amino-4-methyl-1-(difluoromethoxy)benzene; 1-(Difluoromethoxy)-5-methyl-2-aminobenzene; 2-(Difluoromethoxy)-5-methylbenzenamine; 5-Methyl-2-(difluoromethoxy)phenylamine; 2-(Difluoromethoxy)-p-toluidine; Aniline, 2-(difluoromethoxy)-5-methyl-; 832739-40-9
EINECS	Contact for details

Quality Control

Every batch of 2-(Difluoromethoxy)-5-Methylaniline is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality commitment includes comprehensive testing via HPLC, GC, NMR, and MS to verify identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with each shipment. We support custom synthesis and can tailor specifications to meet specific GMP, ICH Q7, or other regulatory requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature (store away from light), the container should be opaque or stored in dark conditions. For long-term storage, consider under an inert atmosphere (e.g., nitrogen or argon) to prevent potential oxidation.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.