Description

Ethyl 7-(Trifluoromethyl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate is a high-value, fluorinated heterocyclic building block essential for advanced organic synthesis. This compound is specifically engineered to introduce the pyrazolopyrimidine pharmacophore and a metabolically stable trifluoromethyl group into target molecules, enhancing their biological activity and physicochemical properties. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, anticancer agents, and other small molecule therapeutics targeting the pyrazolopyrimidine scaffold.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and metabolic stability.
• Material Science Precursor: Serves as a specialized monomer or building block for creating functional polymers and advanced organic electronic materials.
• Chemical Biology Probe: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a fragment in fragment-based drug discovery (FBDD).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for the production of bespoke compounds and libraries for high-throughput screening.

Basic Information

Product Name	Ethyl 7-(Trifluoromethyl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate
CAS No.	832138-80-4
Molecular Formula	C10H8F3N3O2
Molecular Weight	259.19 g/mol
Synonyms	7-(Trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester; Ethyl 7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate; 832138-80-4; Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 7-(trifluoromethyl)-, ethyl ester; Ethyl 7-trifluoromethylpyrazolo[1,5-a]pyrimidine-3-carboxylate; 7-Trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl 7-(Trifluoromethyl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and consistency for your critical R&D and scale-up processes. A detailed Certificate of Analysis (COA), confirming identity, purity, and impurity profiles via validated methods (HPLC, NMR, MS), is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.