Description

Boc-(S)-2-(Aminomethyl)-4-Methylpentanoic Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block for the construction of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the development of novel bioactive molecules.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a protected leucine-like side chain with an aminomethyl functional handle.
• Medicinal Chemistry & Drug Discovery: Employed in structure-activity relationship (SAR) studies and the design of peptide-based therapeutics, enzyme inhibitors, and receptor ligands.
• Bioconjugation: The Boc-protected amine and carboxylic acid groups provide orthogonal reactivity for site-specific labeling and conjugation strategies in biopharmaceuticals.
• Chemical Biology Probes: Integral for creating customized amino acid analogs used as probes to study enzyme mechanisms and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized, non-standard amino acid derivatives.

Basic Information

Product Name	Boc-(S)-2-(Aminomethyl)-4-Methylpentanoic Acid
CAS No.	828254-18-8
Molecular Formula	C12H23NO4
Molecular Weight	245.32 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonylamino)methyl)-4-methylpentanoic acid; Boc-Aminomethyl-L-leucine; Boc-L-Leu(aminomethyl); N-Boc-2-(Aminomethyl)-4-methylpentanoic acid; (S)-N-(tert-Butoxycarbonyl)-2-(aminomethyl)-4-methylpentanoic acid; 2-((((2-Methyl-2-propanyl)oxy)carbonyl)amino)methyl)-4-methyl-(S)-pentanoic acid; Boc-Amm-Leu-OH
EINECS	Contact for details

Quality Control

Our Boc-(S)-2-(Aminomethyl)-4-Methylpentanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.