Description

5-Thiophen-2-Yl-7-Trifluoromethyl-4,5,6,7-Tetrahydro-Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid Ethyl Ester is a high-value, heterocyclic organic compound that serves as a critical advanced pharmaceutical intermediate and building block in modern synthetic chemistry. Its unique molecular architecture, featuring fused pyrazole and pyrimidine rings with a thiophene substituent, makes it indispensable for the research and development of novel active pharmaceutical ingredients (APIs). This compound is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in creating new therapeutic agents, particularly in areas requiring complex, functionalized heterocycles.

Application

This specialized chemical intermediate is designed for advanced synthetic applications, particularly in regulated industries where precision and purity are paramount.

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new pharmacophores.
• Organic Synthesis: Serves as a versatile precursor for further functionalization, enabling the creation of complex molecular libraries for high-throughput screening.
• Agrochemical Development: Potential application as an intermediate in the synthesis of new generation pesticides and herbicides requiring specific heterocyclic activity.
• Material Science Research: Exploration of its use in the development of organic electronic materials due to its conjugated system and heteroatom content.

Basic Information

Product Name	5-Thiophen-2-Yl-7-Trifluoromethyl-4,5,6,7-Tetrahydro-Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid Ethyl Ester
CAS No.	827592-52-9
Molecular Formula	C15H14F3N3O2S
Molecular Weight	357.35 g/mol
Synonyms	Ethyl 5-(thiophen-2-yl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate; 5-(2-Thienyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester; 827592-52-9; Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 4,5,6,7-tetrahydro-5-(2-thienyl)-7-(trifluoromethyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) detailing key parameters such as assay (HPLC), related substances, and residual solvents. Our quality commitment supports compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.