Description

5,7-Bis-Difluoromethyl-Pyrazolo[1,5-A]Pyrimidine is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of difluoromethyl groups can dramatically alter biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate this unique fluorinated scaffold into their molecular designs.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorinated pyrazolopyrimidine core enhances efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or functional additive in the research of advanced polymers and electronic materials.
• Chemical Biology Probe: Employed in the design of molecular probes and enzyme inhibitors for biochemical and pharmacological studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring specialized fluorinated heterocycles.

Basic Information

Product Name	5,7-Bis-Difluoromethyl-Pyrazolo[1,5-A]Pyrimidine
CAS No.	827586-41-4
Molecular Formula	C9H5F4N3
Molecular Weight	231.15 g/mol
Synonyms	5,7-Bis(difluoromethyl)pyrazolo[1,5-a]pyrimidine; 5,7-Bis(difluoromethyl)-1H-pyrazolo[1,5-a]pyrimidine; Pyrazolo[1,5-a]pyrimidine, 5,7-bis(difluoromethyl)-; 827586-41-4; 5,7-Di(difluoromethyl)pyrazolo[1,5-a]pyrimidine
EINECS	Contact for details

Quality Control

Our 5,7-Bis-Difluoromethyl-Pyrazolo[1,5-A]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.