Description

2-Chloro-n-(4-Hydroxyphenyl)-n-Methylquinazolin-4-Amine is a specialized quinazoline derivative, a high-value chemical intermediate with significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and hydroxyphenyl substituents, makes it a critical building block for constructing complex pharmacologically active molecules. This compound is primarily needed by research institutions and pharmaceutical development companies engaged in the discovery and synthesis of new drug candidates, particularly in oncology and targeted therapies.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel small-molecule drug candidates, especially kinase inhibitors.
• Chemical Research & Development: Used as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the multi-step synthesis of potential active pharmaceutical ingredients targeting specific biological pathways.
• Biochemical Tool Compound: Can be utilized in biochemical assays to study enzyme inhibition and cellular signaling mechanisms.
• Custom Synthesis Building Block: Provides a functionalized core for contract research organizations (CROs) and custom synthesis manufacturers.

Basic Information

Product Name	2-Chloro-n-(4-Hydroxyphenyl)-n-Methylquinazolin-4-Amine
CAS No.	827030-83-1
Molecular Formula	C₁₅H₁₂ClN₃O
Molecular Weight	285.73 g/mol
Synonyms	2-Chloro-N-(4-hydroxyphenyl)-N-methyl-4-quinazolinamine; 4-Quinazolinamine, 2-chloro-N-(4-hydroxyphenyl)-N-methyl-; 2-Chloro-N-methyl-N-(4-hydroxyphenyl)quinazolin-4-amine; N-(4-Hydroxyphenyl)-2-chloro-N-methylquinazolin-4-amine; 827030-83-1; Quinazoline derivative 827030-83-1
EINECS	Contact for details

Quality Control

Our 2-Chloro-n-(4-Hydroxyphenyl)-n-Methylquinazolin-4-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive analytical data, including HPLC chromatograms and spectroscopic evidence (NMR, MS). Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.