Description

Fmoc-L-Cys(Palm)-Oh is a specialized, side-chain protected amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is critical for the controlled introduction of S-palmitoylated cysteine residues, a key post-translational modification, into synthetic peptide chains. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and biochemical research, enabling the study of lipidated proteins and the creation of novel therapeutic peptides.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid for the automated synthesis of peptides containing palmitoylated cysteine.
• Lipopeptide Drug Development: For constructing potential therapeutic agents that mimic naturally occurring lipidated peptides, such as hormones and antimicrobial peptides.
• Bioconjugation and Protein Labeling: Used to introduce a hydrophobic palmitoyl anchor onto peptides for membrane association studies or sensor development.
• Academic and Industrial Research: A key reagent in studying protein S-palmitoylation, membrane protein structure, and intracellular signaling pathways.
• Production of Diagnostic Reagents: For creating peptide antigens or probes used in immunoassays and diagnostic kits.
• Material Science: Employed in the synthesis of peptide-based biomaterials and surfaces where controlled hydrophobicity is required.

Basic Information

Product Name	Fmoc-L-Cys(Palm)-Oh
CAS No.	824955-27-3
Molecular Formula	C₃₀H₃₉NO₅S
Molecular Weight	525.70 g/mol
Synonyms	Fmoc-Cys(Palmitoyl)-OH; N-(9-Fluorenylmethoxycarbonyl)-S-palmitoyl-L-cysteine; Fmoc-L-cysteine(S-palmitoyl) free acid; Fmoc-Cys(Palm)-OH; Nα-Fmoc-S-palmitoyl-L-cysteine; (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(palmitoylsulfanyl)propanoic acid; Fmoc-Cys(Palm); Fmoc-S-palmitoyl-L-cysteine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-L-Cys(Palm)-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure high purity and consistency to meet the exacting standards of peptide synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, reporting key parameters such as assay (HPLC), chiral purity, and identity. Our quality commitment supports applications in GMP-compliant research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation. For long-term stability, store under inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.