Description

1-[4-Amino-7-(3-Hydroxypropyl)-5-(4-Methylphenyl)-7H-Pyrrolo[2,3-D]Pyrimidin-6-Yl]-2-Chloro-Ethanone is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, particularly in the creation of targeted kinase inhibitors. It is primarily sought by pharmaceutical manufacturers, biotechnology research firms, and contract development and manufacturing organizations (CDMOs) engaged in the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel kinase inhibitor drugs targeting various cancers and inflammatory diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• Process Development: Serves as a critical starting material or intermediate in scaling up API manufacturing processes from laboratory to commercial scale.
• Biochemical Research: Employed in the development of assay kits and probes for studying specific enzymatic pathways and cellular signaling mechanisms.
• Custom Synthesis: A foundational compound for contract research organizations (CROs) and CDMOs offering bespoke synthesis services for client-specific drug discovery programs.

Basic Information

Product Name	1-[4-Amino-7-(3-Hydroxypropyl)-5-(4-Methylphenyl)-7H-Pyrrolo[2,3-D]Pyrimidin-6-Yl]-2-Chloro-Ethanone
CAS No.	821794-90-5
Molecular Formula	C₁₈H₁₉ClN₄O₂
Molecular Weight	358.82 g/mol
Synonyms	2-Chloro-1-[4-amino-7-(3-hydroxypropyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]ethanone; 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-chloroethanone; 2-Chloro-1-(4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)ethan-1-one; 821794-90-5; Pyrrolo[2,3-d]pyrimidine intermediate; Kinase inhibitor intermediate
EINECS	Contact for details

Quality Control

Our 1-[4-Amino-7-(3-Hydroxypropyl)-5-(4-Methylphenyl)-7H-Pyrrolo[2,3-D]Pyrimidin-6-Yl]-2-Chloro-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.