Description

7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine, 6-Bromo-7-[3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Propyl]-5-(4-Methylphenyl)- is a sophisticated, multi-functional heterocyclic building block designed for advanced organic synthesis. This compound is a critical intermediate in the development of targeted small molecule therapeutics, offering a unique scaffold for medicinal chemistry research. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers specializing in the synthesis of kinase inhibitors and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel kinase inhibitors and other targeted cancer therapies.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probes: Serves as a precursor for developing molecular probes to study specific enzyme functions and signaling pathways.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of complex, high-value active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug design.

Basic Information

Item	Details
Product Name	7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine, 6-Bromo-7-[3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Propyl]-5-(4-Methylphenyl)-
CAS No.	821794-85-8
Molecular Formula	C22H31BrN4OSi
Molecular Weight	475.50 g/mol
Synonyms	6-Bromo-7-(3-((tert-butyldimethylsilyl)oxy)propyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 6-Bromo-5-(4-methylphenyl)-7-[3-[(tert-butyldimethylsilyl)oxy]propyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine; TBDMS-protected pyrrolopyrimidine intermediate; Kinase inhibitor intermediate SC-3; CAS 821794-85-8
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems to ensure consistency and purity for sensitive pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by HPLC, NMR, and mass spectrometry. Our quality commitment aligns with the standards expected for GMP-grade starting materials and non-GMP research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.