Description

1-[4-Amino-7-(3-tert-Butyldimethylsilyloxypropyl)-5-(4-Methylphenyl)-7H-Pyrrolo[2,3-D]Pyrimidine is a sophisticated pyrrolopyrimidine derivative, a key chemical building block valued for its role in advanced pharmaceutical synthesis. This compound is specifically engineered for use as a critical intermediate in the development of targeted therapeutic agents, particularly kinase inhibitors. It is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical suppliers focused on oncology and other specialized drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel kinase inhibitors and other small-molecule active pharmaceutical ingredients (APIs).
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in oncology and immunology research programs.
• Chemical Biology Probe Synthesis: Serves as a scaffold for creating molecular probes to study specific enzyme functions and cellular signaling pathways.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific novel chemical entities.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and pharmaceutical sciences.

Basic Information

Product Name	1-[4-Amino-7-(3-tert-Butyldimethylsilyloxypropyl)-5-(4-Methylphenyl)-7H-Pyrrolo[2,3-D]Pyrimidine
CAS No.	821794-84-7
Molecular Formula	C22H34N4OSi
Molecular Weight	398.63 g/mol
Synonyms	1-[4-Amino-7-[3-[(1,1-Dimethylethyl)dimethylsilyl]oxy]propyl]-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine; 4-Amino-7-(3-((tert-butyldimethylsilyl)oxy)propyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidine; 1-[4-Amino-7-(3-tert-Butyldimethylsilyloxypropyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidine; TBDMS-protected Pyrrolopyrimidine Intermediate; 821794-84-7
EINECS	Contact for details

Quality Control

Our 1-[4-Amino-7-(3-tert-Butyldimethylsilyloxypropyl)-5-(4-Methylphenyl)-7H-Pyrrolo[2,3-D]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your internal quality standards and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.