Description

2,4(1H,3H)-Pyrimidinedione, 1-[(1R,3R)-3-Hydroxycyclopentyl]-5-Methyl-, Rel- is a high-purity, stereochemically defined pyrimidinedione derivative. This compound is a critical chiral building block and intermediate in advanced pharmaceutical synthesis, valued for its precise molecular architecture. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in antiviral and anticancer research.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex active pharmaceutical ingredients (APIs).
• Antiviral Drug Research: Used as a building block in the development of nucleoside/nucleotide analog prodrugs targeting viral polymerases.
• Oncology Research: Employed in the discovery and synthesis of potential small-molecule inhibitors for cancer therapy.
• Process Chemistry & Scale-Up: Supports route scouting, optimization, and cGMP manufacturing for clinical trial material.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies and mechanism of action investigations.
• Custom Synthesis: A starting point for the preparation of more complex, tailored molecular libraries for screening.

Basic Information

Product Name	2,4(1H,3H)-Pyrimidinedione, 1-[(1R,3R)-3-Hydroxycyclopentyl]-5-Methyl-, Rel-
CAS No.	820988-83-8
Molecular Formula	C10H14N2O3
Molecular Weight	210.23 g/mol
Synonyms	rel-1-[(1R,3R)-3-Hydroxycyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione; (1R,3R)-3-((5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)cyclopentanol; 5-Methyl-1-((1R,3R)-3-hydroxycyclopentyl)dihydropyrimidine-2,4(1H,3H)-dione; Chiral Cyclopentyl Pyrimidinedione Derivative; Pharmaceutical Intermediate 820988-83-8
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to guarantee identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing lot-specific results are available upon request. Our quality management system supports development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.