Description

6-Methyl-2-Oxo-4-(4-(Trifluoromethyl)Phenyl)-1,2,3,4-Tetrahydropyrimidine-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a defined dihydropyrimidine scaffold. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular structures. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug molecules, especially those targeting central nervous system (CNS) disorders, inflammation, or metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides, leveraging the biological activity of the dihydropyrimidine core.
• Chemical Synthesis Building Block: Employed in organic synthesis for constructing complex heterocyclic compounds in medicinal chemistry programs.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) laboratories for pharmacological screening and structure-activity relationship (SAR) studies.
• Material Science Precursor: Investigated for the development of specialty polymers or organic electronic materials due to its aromatic and heterocyclic properties.

Basic Information

Product Name	6-Methyl-2-Oxo-4-(4-(Trifluoromethyl)Phenyl)-1,2,3,4-Tetrahydropyrimidine-5-Carboxylic Acid
CAS No.	817200-49-0
Molecular Formula	C14H11F3N2O3
Molecular Weight	312.25 g/mol
Synonyms	4-(4-(Trifluoromethyl)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid; 6-Methyl-4-[4-(trifluoromethyl)phenyl]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid; DHPM derivative; Biginelli reaction product; 1,2,3,4-Tetrahydropyrimidine-5-carboxylic acid, 6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our 6-Methyl-2-Oxo-4-(4-(Trifluoromethyl)Phenyl)-1,2,3,4-Tetrahydropyrimidine-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure compliance with stringent specifications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.