Description

4-(4-Fluorophenyl)-n-(1H-Indazol-5-Yl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxamide is a high-purity, advanced pharmaceutical intermediate of significant interest in modern drug discovery. This compound matters for its role as a key building block in the synthesis of novel therapeutic agents, particularly kinase inhibitors. Pharmaceutical R&D and fine chemical synthesis laboratories need this material for developing targeted treatments in oncology and inflammatory diseases.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel small-molecule kinase inhibitors for targeted cancer therapies.
• Biochemical Research: Used as a reference standard or active compound in high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Medicinal Chemistry: Serves as a core scaffold for the design and optimization of new chemical entities (NCEs) with potential anti-proliferative activity.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations engaged in custom synthesis and process development for clinical trial materials.
• Academic Research: Utilized in university and institutional labs for investigating novel signaling pathways and drug mechanisms of action.

Basic Information

Product Name	4-(4-Fluorophenyl)-n-(1H-Indazol-5-Yl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxamide
CAS No.	817194-38-0
Molecular Formula	C21H18FN5O2
Molecular Weight	391.40 g/mol
Synonyms	4-(4-Fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide; 4-(4-Fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide; 817194-38-0; CHEMBL3186605; BDBM50157887; AKOS015915889; ZINC000003869007; Tetrahydropyrimidine-5-carboxamide derivative
EINECS	Contact for details

Quality Control

Our 4-(4-Fluorophenyl)-n-(1H-Indazol-5-Yl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxamide is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research and development grade standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.