Description

Fmoc-Glu(Biotinyl-Peg)-Oh is a sophisticated, multi-functional building block designed for advanced bioconjugation and peptide synthesis. This compound integrates an Fmoc-protected glutamic acid residue with a biotin moiety via a flexible polyethylene glycol (PEG) linker, enabling precise, site-specific labeling and purification strategies. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay creation, where high-affinity biotin-streptavidin interactions are leveraged.

Application

• Solid-Phase Peptide Synthesis (SPPS): Used as an Fmoc-protected amino acid derivative for the controlled incorporation of biotin labels into custom peptide sequences.
• Bioconjugation and Protein Labeling: Facilitates the site-specific biotinylation of proteins, antibodies, and other biomolecules for detection, pull-down assays, and immobilization.
• Diagnostic Kit Development: A key component in the manufacture of ELISA, lateral flow assays, and other diagnostic tools that utilize streptavidin-biotin technology for signal amplification.
• Affinity Purification Probes: Enables the creation of tagged peptides or small molecules for isolating target proteins or studying protein-protein interactions.
• Drug Delivery System Research: The PEG spacer enhances solubility and reduces steric hindrance, making it valuable for designing targeted drug conjugates and biotherapeutic linkers.
• Chemical Biology and Probe Design: Serves as a versatile scaffold for creating activity-based probes and molecular tools to study biological processes.

Basic Information

Product Name	Fmoc-Glu(Biotinyl-Peg)-Oh
CAS No.	817169-73-6
Molecular Formula	C₄₀H₅₄N₄O₁₀S
Molecular Weight	782.95 g/mol
Synonyms	Fmoc-Glu(Biotin-PEG)-OH; N-α-Fmoc-N-γ-(biotinyl-PEG)-L-glutamic acid; Fmoc-L-Glu(biotinyl-PEG)-OH; Fmoc-Glu(Biotin-PEG)-OH linker; Biotin-PEG-Fmoc-Glu-OH; (9H-Fluoren-9-yl)methyl (2S)-4-[(2-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamido}ethoxy)ethoxy]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}butanoate; Fmoc protected biotinylated glutamic acid PEG derivative
EINECS	Contact for details

Quality Control

Our Fmoc-Glu(Biotinyl-Peg)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and cGMP applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity, purity, and correct structure. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.