Description

4-Fluoro-3-(Methoxycarbonyl)Benzyl Alcohol, [4-Fluoro-3-(Methoxycarbonyl)Phenyl]Methanol is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters because it provides a versatile scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorinated motifs and functional handles into their target structures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and oncology therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom can enhance biological activity, stability, and metabolic profile.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorinated benzyl alcohol groups into polymer chains, altering material properties like solubility, thermal stability, and surface energy.
• Cross-Coupling Reactions: The benzyl alcohol moiety can be transformed into various functional groups, making it a versatile substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions.
• Protecting Group Chemistry: Utilized in multi-step synthetic routes where the alcohol group requires protection and subsequent deprotection.

Basic Information

Product Name	4-Fluoro-3-(Methoxycarbonyl)Benzyl Alcohol, [4-Fluoro-3-(Methoxycarbonyl)Phenyl]Methanol
CAS No.	816449-70-4
Molecular Formula	C10H11FO3
Molecular Weight	198.19 g/mol
Synonyms	(4-Fluoro-3-(methoxycarbonyl)phenyl)methanol; Methyl 4-Fluoro-3-(hydroxymethyl)benzoate; 3-(Hydroxymethyl)-4-fluorobenzoic Acid Methyl Ester; 4-Fluoro-3-(hydroxymethyl)benzoic Acid Methyl Ester; Methyl 3-(Hydroxymethyl)-4-fluorobenzoate; 816449-70-4; Benzenemethanol, 4-fluoro-3-(methoxycarbonyl)-
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(Methoxycarbonyl)Benzyl Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to light and propensity for oxidation, it is recommended to store this material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.