Description

Benzenemethanesulfonamide, Alpha,α-Difluoro-4-Methyl- (9Ci) is a specialized fluorinated sulfonamide derivative, a high-value building block in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the difluoromethylene group adjacent to the sulfonamide, making it a critical intermediate for constructing complex molecules with tailored properties. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides where the introduction of fluorine atoms can improve efficacy and environmental profile.
• Material Science Research: Acts as a precursor for specialty polymers and advanced materials, where the sulfonamide and fluorine groups can modify surface properties and chemical resistance.
• Ligand and Catalyst Development: Employed in the synthesis of complex ligands for catalysis and molecular recognition studies in both academic and industrial settings.
• Fluorine Chemistry Building Block: A versatile reagent for introducing the -CF2- moiety into target molecules, a common strategy in modern medicinal and synthetic chemistry.

Basic Information

Product Name	Benzenemethanesulfonamide, Alpha,α-Difluoro-4-Methyl- (9Ci)
CAS No.	803728-11-2
Molecular Formula	C8H9F2NO2S
Molecular Weight	221.23 g/mol
Synonyms	α,α-Difluoro-4-methylbenzenemethanesulfonamide; 4-Methyl-α,α-difluorobenzenemethanesulfonamide; N-(Difluoro(p-tolyl)methyl)sulfamide; p-Tolyl(difluoro)methanesulfonamide; 1-(Difluoro(p-tolyl)methyl)sulfonyl]amine; (4-Methylphenyl)(difluoro)methanesulfonamide; Benzenemethanesulfonamide, α,α-difluoro-4-methyl-
EINECS	Contact for details

Quality Control

Every batch of Benzenemethanesulfonamide, Alpha,α-Difluoro-4-Methyl- (9Ci) is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, NMR, and GC-MS, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.