Description

Pyrimidine, 1,4,5,6-Tetrahydro-2-(o-Methylstyryl)-, (E)- (8Ci) is a specialized organic compound belonging to the tetrahydro-pyrimidine class, featuring a distinct (E)-configured o-methylstyryl substituent. This precise molecular architecture makes it a valuable advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. The compound's defined stereochemistry and functional groups enable its use in creating targeted molecules with specific biological activities.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly in therapeutic areas requiring complex heterocyclic scaffolds.
• Medicinal Chemistry Building Block: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Synthesis: Serves as an intermediate in the development of novel pesticides, herbicides, or fungicides with enhanced efficacy.
• Chemical Research & Development: Employed in academic and industrial labs for methodological studies, such as cyclization reactions or asymmetric synthesis.
• Ligand and Catalyst Development: Potential use in the synthesis of specialized ligands for catalysis or metal-organic frameworks (MOFs).
• Fine Chemical Production: Integrated into multi-step synthesis processes for producing high-value, low-volume specialty chemicals.

Basic Information

Product Name	Pyrimidine, 1,4,5,6-Tetrahydro-2-(o-Methylstyryl)-, (E)- (8Ci)
CAS No.	801195-65-3
Molecular Formula	C13H16N2
Molecular Weight	200.28 g/mol
Synonyms	(E)-2-(2-Methylstyryl)-1,4,5,6-tetrahydropyrimidine; (E)-1,4,5,6-Tetrahydro-2-(2-methylstyryl)pyrimidine; 2-[(1E)-2-(2-Methylphenyl)ethenyl]-1,4,5,6-tetrahydropyrimidine; (E)-2-(o-Methylstyryl)-1,4,5,6-tetrahydropyrimidine; 801195-65-3; Tetrahydro-2-(o-methylstyryl)pyrimidine (E)-isomer
EINECS	Contact for details

Quality Control

Our Pyrimidine, 1,4,5,6-Tetrahydro-2-(o-Methylstyryl)-, (E)- (8Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each batch is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity, purity, and isomeric composition. Certificates of Analysis (COA) detailing all relevant specifications are provided and available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Isomeric Purity (E/Z Ratio)	≥ 98:2 (E:Z)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.