Description

(Asp56)-Pth (1-84) (Rat) is a synthetic peptide fragment corresponding to a specific region of the rat parathyroid hormone (PTH) protein. This compound is a critical research-grade biochemical tool used for studying PTH structure, function, and receptor interactions. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies focused on endocrine research, bone metabolism studies, and the development of novel therapeutics for conditions like osteoporosis and hyperparathyroidism.

Application

• Biochemical Research: Used as a reference standard and active agent in studies investigating the structure-activity relationship (SAR) of parathyroid hormone.
• Receptor Binding Assays: Essential for in vitro competitive binding studies to characterize PTH receptor (PTH1R) affinity and specificity.
• Cell Signaling Studies: Applied in cellular models to stimulate cAMP production and analyze downstream signaling pathways related to calcium and phosphate homeostasis.
• Antibody Production & Immunoassays: Serves as an immunogen for generating specific antibodies or as a calibrator in ELISA and other immunoassay development for PTH detection.
• Pharmaceutical Development: Used in preclinical research for screening and evaluating potential PTH analogs or antagonists as drug candidates.

Basic Information

Product Name	(Asp56)-Pth (1-84) (Rat)
CAS No.	89899-56-9
Molecular Formula	C411H679N125O126S2
Molecular Weight	9427.6 g/mol (theoretical)
Synonyms	Rat PTH (1-84) [Asp56]; Parathyroid Hormone (1-84), Rat; PTH (1-84) Rat; rPTH(1-84); Asp56-PTH(1-84); Parathyrin (1-84) fragment with Asp at position 56 (Rat); N/A
EINECS	Contact for details

Quality Control

Our (Asp56)-Pth (1-84) (Rat) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and Mass Spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and biological activity (where applicable) are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture absorption. Aliquot into single-use vials after reconstitution to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.