Description

n-Me-Hyp-Oh·Hcl CAS NO 89771-43-7 is a specialized amino acid derivative, specifically a hydrochloride salt of a modified hydroxyproline. This compound is valued for its role as a high-purity building block in advanced organic synthesis and pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the development of novel therapeutic agents and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs and protease inhibitors.
• Bioconjugation & Linker Chemistry: Used in the development of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Peptidomimetic Research: Serves as a constrained scaffold for designing novel bioactive peptides with enhanced stability and potency.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and probes for studying enzyme mechanisms and protein interactions.
• Cosmetic & Dermatological Actives: Incorporated into advanced formulations for skin conditioning and anti-aging products.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	n-Me-Hyp-Oh·Hcl
CAS No.	89771-43-7
Molecular Formula	C6H12ClNO3
Molecular Weight	181.62 g/mol
Synonyms	N-Methyl-L-hydroxyproline hydrochloride; (2S,4R)-1-Methyl-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride; trans-4-Hydroxy-N-methyl-L-proline hydrochloride; L-Hydroxy-N-methylproline HCl; Methylhydroxyproline HCl; 1-Methyl-4-hydroxyproline hydrochloride; 4-Hydroxy-1-methyl-L-proline hydrochloride
EINECS	Contact for details

Quality Control

Every batch of n-Me-Hyp-Oh·Hcl is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay, chiral purity, and impurity profiles. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.