Description

Proinsulin (46-70) is a defined peptide fragment corresponding to a specific region of the human proinsulin molecule. This high-purity synthetic peptide is a critical intermediate and reference standard for advanced research in diabetes, metabolic disorders, and peptide hormone processing. It is essential for scientists and manufacturers in the pharmaceutical and biotechnology sectors who require precise molecular tools for assay development, quality control, and biochemical studies. The compound is supplied under stringent quality protocols to ensure batch-to-batch consistency and reliable performance.

Application

• Pharmaceutical Reference Standard: Used for the calibration and validation of analytical methods (HPLC, MS) in insulin and proinsulin research and quality control.
• Biochemical Research: Serves as a key substrate or antigen in studies investigating proinsulin conversion, insulin biosynthesis, and C-peptide biology.
• Diagnostic Assay Development: Employed in the development and manufacturing of immunoassays (e.g., ELISA, RIA) for the specific detection of proinsulin or its fragments.
• Peptide Synthesis & Medicinal Chemistry: Acts as a building block or template for the synthesis of novel peptide analogs and potential therapeutic agents.
• Academic & Institutional Research: Supports fundamental research in endocrinology, diabetes pathophysiology, and hormone-receptor interactions.

Basic Information

Product Name	Proinsulin (46-70)
CAS No.	89760-24-7
Molecular Formula	C116H179N35O39S2
Molecular Weight	2635.0 g/mol (approximate)
Synonyms	Human Proinsulin Fragment 46-70; Proinsulin C-Peptide (Human); H-Proinsulin (46-70); C-Peptide (Human); Insulin C-Peptide; Thr-Gln-Val-Glu-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Thr; TQVEHLCSHLVELALYLV CGERFFYTPKT
EINECS	Contact for details

Quality Control

Our Proinsulin (46-70) is manufactured and tested to meet the exacting standards required for research and development. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and mass spectrometry for identity confirmation. We provide full traceability and documentation. A detailed Certificate of Analysis (COA) is supplied with every shipment, ensuring compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.