Description

Enkephalin-Leu, 4'-Bromo-Phe(4)- CAS NO 89705-56-6 is a synthetic, modified peptide analog of the endogenous opioid peptide enkephalin, incorporating a brominated phenylalanine residue. This specific modification is crucial for enhancing receptor binding affinity and metabolic stability, making it a valuable tool for advanced neuropharmacological research. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, pain management, and opioid receptor studies.

Application

• Neuroscience Research: A key biochemical tool for studying the structure-activity relationships (SAR) of opioid peptides and their interactions with delta (δ) and mu (μ) opioid receptors.
• Drug Discovery & Development: Serves as a reference standard or a lead compound in the design of novel, non-addictive analgesics and neurotherapeutics with improved pharmacokinetic profiles.
• Biochemical Assays: Used in competitive binding assays, receptor autoradiography, and functional studies to characterize opioid receptor subtypes and signaling pathways.
• Metabolic Stability Studies: Employed to investigate the effects of halogenation on peptide degradation by endogenous peptidases, informing the design of more stable peptide-based drugs.
• Academic & Clinical Research: Supports fundamental research into the endogenous opioid system, its role in pain modulation, addiction, and mood disorders.

Basic Information

Product Name	Enkephalin-Leu, 4'-Bromo-Phe(4)-
CAS No.	89705-56-6
Molecular Formula	C30H39BrN6O7
Molecular Weight	675.57 g/mol
Synonyms	4'-Bromo-Phe(4)-Enkephalin-Leu; [4'-Bromo-Phe4]-Leu-Enkephalin; H-Tyr-Gly-Gly-Phe(4-Br)-Leu-OH; Leu-Enkephalin, [4'-Bromo-Phe4]-; Brominated Leu-Enkephalin; Opioid Peptide Analog; YGGFL(4-Br)
EINECS	Contact for details

Quality Control

Our Enkephalin-Leu, 4'-Bromo-Phe(4)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and MS for identity confirmation, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.