Description

Ac-Pro-Leu-Gly-Oh is a synthetic tetrapeptide derivative featuring an acetylated N-terminus and a free C-terminal carboxylic acid. This compound serves as a crucial building block and reference standard in advanced biochemical research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and peptide synthesis sectors for developing novel therapeutic agents and studying enzyme-substrate interactions.

Application

• Pharmaceutical Intermediate: Used in the research and synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Biochemical Research: Serves as a substrate, inhibitor, or reference standard in enzymatic studies and proteomics research.
• Peptide Library Construction: Acts as a key building block in solid-phase and solution-phase peptide synthesis for creating diverse compound libraries.
• Protease Specificity Studies: Employed to investigate the cleavage specificity and kinetics of various proteolytic enzymes.
• Cosmetic Peptide Development: Utilized in the formulation research of bioactive peptides for advanced skincare and cosmetic applications.
• Academic & Institutional Research: Provides a defined peptide sequence for fundamental studies in biochemistry, molecular biology, and medicinal chemistry.

Basic Information

Item	Details
Product Name	Ac-Pro-Leu-Gly-Oh
CAS No.	89626-38-0
Molecular Formula	C17H28N4O5
Molecular Weight	368.43 g/mol
Synonyms	Acetyl-Prolyl-Leucyl-Glycine; Ac-Pro-Leu-Gly-OH; N-Acetyl-L-prolyl-L-leucyl-glycine; Ac-PLG-OH; Ac-Pro-Leu-Gly; APLG; N-Acetyl-Pro-Leu-Gly; Tetrapeptide-3 (cosmetic ingredient name)
EINECS	Contact for details

Quality Control

Our Ac-Pro-Leu-Gly-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific research or cGMP requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.