Description

1-Methyl-L-Proline Hcl CAS NO 89614-97-1 is a high-purity, non-proteinogenic amino acid derivative, specifically a methylated proline hydrochloride salt. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, offering precise stereochemical control. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors developing novel therapeutics, peptide mimetics, and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting neurological and metabolic disorders.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce conformational constraints and modify peptide backbone properties.
• Bioconjugation & Probe Development: Serves as a linker or spacer molecule in the development of biochemical probes, diagnostic agents, and antibody-drug conjugates (ADCs).
• Asymmetric Catalysis: Employed as a precursor for chiral ligands and organocatalysts used in stereoselective transformations.
• Biochemical Research: Utilized in enzymatic studies and as a standard in analytical method development for amino acid analysis.
• Cosmetic & Personal Care Actives: Investigated for use in advanced skincare formulations due to its potential role in collagen synthesis and skin barrier function.

Basic Information

Product Name	1-Methyl-L-Proline Hcl
CAS No.	89614-97-1
Molecular Formula	C6H11NO2 • HCl
Molecular Weight	165.62 g/mol (Free base: 129.16)
Synonyms	(2S)-1-Methylpyrrolidine-2-carboxylic acid hydrochloride; L-1-Methylproline hydrochloride; (S)-1-Methylproline HCl; 1-Methyl-L-proline monohydrochloride; 1-Methyl-(S)-proline hydrochloride; NSC 163022; (S)-1-Methyl-2-pyrrolidinecarboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Methyl-L-Proline Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical and research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.