Description

(D-Pro4,D-Trp7,9,10,Phe11)-Substance P (4-11) CAS NO 89457-20-5 is a synthetic, biologically active peptide analog of the neuropeptide Substance P. This compound is specifically engineered as a potent and selective antagonist for the neurokinin-1 (NK1) receptor, making it a critical research tool in neuroscience and pharmacology. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies for investigating pain pathways, neurogenic inflammation, and central nervous system disorders.

Application

• Neuroscience Research: As a selective NK1 receptor antagonist for studying the role of Substance P in pain transmission, migraine, and neuroinflammation.
• Pharmacological Studies: Used in in vitro and in vivo assays to characterize receptor binding, signal transduction, and the efficacy of novel therapeutic candidates.
• Drug Discovery & Development: A reference standard and tool compound in high-throughput screening (HTS) campaigns targeting the NK1 receptor for analgesic, anti-emetic, or psychiatric drug development.
• Biochemical Research: Investigation of peptide-receptor interactions, structure-activity relationships (SAR), and the design of more stable peptide analogs.
• Academic & Clinical Research: Fundamental research into the mechanisms of emesis (vomiting), depression, anxiety, and other conditions modulated by the tachykinin system.

Basic Information

Item	Detail
Product Name	(D-Pro4,D-Trp7,9,10,Phe11)-Substance P (4-11)
CAS No.	89457-20-5
Molecular Formula	C66H84N16O10
Molecular Weight	1269.5 g/mol
Synonyms	Substance P (4-11), [D-Pro4, D-Trp7,9,10, Phe11]-Substance P (4-11); [D-Trp7,9,10, D-Pro4, Phe11]-Substance P (4-11); SP (4-11) antagonist; NK1 receptor antagonist (peptide); Neurokinin-1 antagonist peptide; [D-Pro4, D-Trp7,9,10, Phe11]-SP(4-11)
EINECS	Contact for details

Quality Control

Our (D-Pro4,D-Trp7,9,10,Phe11)-Substance P (4-11) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided to ensure compliance with research-grade standards and support your experimental reproducibility.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This hygroscopic (moisture-sensitive) peptide should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis. Aliquotting is recommended to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.