Description

Substance P(4-11), Pro(4)-Trp(7,9,10)-Leunh2(11)- CAS NO 89457-19-2 is a synthetic peptide fragment derived from the neuropeptide Substance P, specifically designed for research and development applications. This compound is a critical tool for investigating the structure-activity relationships of Substance P and its interaction with neurokinin receptors. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, pain management, and inflammatory pathways. The product is supplied to meet the stringent purity and consistency requirements essential for reliable experimental results.

Application

• Neuroscience Research: Used as a selective ligand and antagonist in studies of neurokinin-1 (NK1) receptor signaling and function.
• Pharmacological Assay Development: Serves as a reference standard and active agent in high-throughput screening (HTS) for drug discovery programs targeting neuropeptide pathways.
• Biochemical Studies: Employed to investigate peptide-receptor binding kinetics, signal transduction mechanisms, and downstream cellular effects.
• Academic & Clinical Research: Supports fundamental research into the role of Substance P fragments in pain perception, inflammation, and neurological disorders.
• Peptide Chemistry & Custom Synthesis: Acts as a key intermediate or reference compound for the design and synthesis of novel peptide analogs with modified biological activity.

Basic Information

Product Name	Substance P(4-11), Pro(4)-Trp(7,9,10)-Leunh2(11)- CAS NO 89457-19-2
CAS No.	89457-19-2
Molecular Formula	C58H78N16O9
Molecular Weight	1127.34 g/mol
Synonyms	Substance P (4-11) fragment; [pGlu4, Trp7,9,10, Leu11]-Substance P (4-11); [pGlu4, Trp7,9,10, Leu11]-SP (4-11); SP (4-11) analog; Neurokinin receptor antagonist fragment; Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Trp-Leu-NH2 (modified); pGlu-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Trp-Leu-NH2
EINECS	Contact for details

Quality Control

Every batch of Substance P(4-11), Pro(4)-Trp(7,9,10)-Leunh2(11)- CAS NO 89457-19-2 is manufactured and tested under strict quality management systems to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards for research-grade peptides. Certificates of Analysis (COA) detailing purity, assay results, and chromatographic profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.