Description

Thyrotropin-Releasing Hormone, Gly-Lys-Arg- is a synthetic tripeptide analog of the endogenous thyrotropin-releasing hormone (TRH). This compound is of significant value in biochemical research and pharmaceutical development due to its role in studying the hypothalamic-pituitary-thyroid axis and neuroendocrine signaling. It is primarily needed by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in endocrinology, neuroscience, and peptide-based therapeutic discovery.

Application

• Biomedical Research: Used as a reference standard and tool compound in studies of TRH receptor binding, signal transduction, and hormone release mechanisms.
• Diagnostic Development: Serves as a critical antigen or calibrator in the development of immunoassays for measuring TRH or related hormones.
• Neuropharmacology: Employed in preclinical research to investigate the neurological effects of TRH analogs, including potential applications for CNS disorders.
• Peptide Chemistry: Acts as a building block or intermediate for the synthesis of more complex peptide analogs with modified biological activity.
• Quality Control: Utilized as a system suitability standard in analytical laboratories to validate methods for peptide analysis and purity assessment.

Basic Information

Product Name	Thyrotropin-Releasing Hormone, Gly-Lys-Arg-
CAS No.	89455-78-7
Molecular Formula	C16H28N8O5
Molecular Weight	412.44 g/mol
Synonyms	TRH-Gly-Lys-Arg; Gly-Lys-Arg-TRH; L-Glycyl-L-lysyl-L-arginyl-L-pyroglutamyl-L-histidyl-L-prolinamide; Pyroglutamyl-Histidyl-Prolyl-Glycyl-Lysyl-Arginine; GKR-TRH; TRH Analog (GKR); Thyroliberin (Gly-Lys-Arg-); Protirelin Analog
EINECS	Contact for details

Quality Control

Our Thyrotropin-Releasing Hormone, Gly-Lys-Arg- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.