Description

(D-Ala2)-Grf (1-29) Amide (Human) CAS NO 89453-59-8 is a synthetic peptide analog of human growth hormone-releasing factor (GRF), specifically modified with a D-alanine substitution at position 2 and an amidated C-terminus to enhance its metabolic stability and biological activity. This compound is a critical research tool and a key intermediate in the development of therapeutic agents targeting growth hormone secretion. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on endocrinology, metabolic disorders, and peptide-based drug discovery.

Application

• Biomedical Research: Used as a reference standard and active agent in studies investigating the mechanisms of growth hormone (GH) release and the somatotropic axis.
• Drug Discovery & Development: Serves as a lead compound or intermediate for the synthesis of novel growth hormone secretagogues and analogs with improved pharmacokinetic profiles.
• In Vitro & In Vivo Assays: Employed in cell-based assays and animal models to evaluate the potency, efficacy, and safety of compounds designed to modulate GH secretion.
• Diagnostic Tool Development: Potential use in the development of immunoassays or other diagnostic kits for measuring GRF-related biological activity.
• Peptide Chemistry Studies: Valuable for research on peptide structure-activity relationships (SAR), stability, and formulation science.

Basic Information

Product Name	(D-Ala2)-Grf (1-29) Amide (Human)
CAS No.	89453-59-8
Molecular Formula	C149H246N44O42
Molecular Weight	3359.8 g/mol
Synonyms	[D-Ala2]-hGRF(1-29)-NH2; (D-Ala2) Human GRF (1-29) Amide; Growth Hormone-Releasing Factor (1-29), human, [D-Ala2]-, amide; Sermorelin Acetate Analog; GHRH (1-29), human, [D-Ala2]-, amide; GRF (1-29) (human) [D-Ala2] amide; Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
EINECS	Contact for details

Quality Control

Our (D-Ala2)-Grf (1-29) Amide (Human) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide Certificates of Analysis (COA) detailing all specifications to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation. Aliquot into single-use vials to minimize repeated freeze-thaw cycles and exposure to air.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by AAA)
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC/IC)	≤ 15.0%
Biological Activity	Assessed by in vitro GH release assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.