Description

Substance P (4-11), Pro(4)-Trp(7,9)-Phenh2(11)- is a bioactive peptide fragment derived from the neuropeptide Substance P. This compound is valued for its high specificity and potency in scientific research, particularly in the study of neurokinin receptors and related signaling pathways. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for biochemical and pharmacological investigations.

Application

• Neuroscience Research: Used as a selective ligand for studying the structure and function of neurokinin-1 (NK1) receptors.
• Pharmacological Assays: Serves as a key reference standard in receptor binding studies and functional bioassays to evaluate antagonist activity.
• Drug Discovery: Employed in high-throughput screening (HTS) platforms to identify and characterize novel analgesic or anti-inflammatory compounds.
• Biochemical Studies: Utilized to investigate peptide-receptor interactions, signal transduction mechanisms, and the role of Substance P in pain and inflammation.
• Academic Research: A critical tool for universities and research institutes exploring neuropeptide biology and central nervous system disorders.

Basic Information

Product Name	Substance P (4-11), Pro(4)-Trp(7,9)-Phenh2(11)-
CAS No.	89430-36-4
Molecular Formula	C55H72N14O9
Molecular Weight	1049.2 g/mol
Synonyms	Substance P (4-11) fragment; [Pro4, Trp7,9, Phe11]-Substance P (4-11); Substance P (4-11), [pGlu6, Pro9]-; [pGlu6, Pro9]-Substance P (4-11); Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (modified); SP (4-11) analog; Neurokinin receptor ligand; NK1 receptor agonist fragment
EINECS	Contact for details

Quality Control

Our Substance P (4-11), Pro(4)-Trp(7,9)-Phenh2(11)- is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and MS for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the peptide desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.