Description

D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Nle-Nh2 CAS NO 89430-34-2 is a synthetic peptide analog of growth hormone-releasing hormone (GHRH). This compound is significant for its potent and selective biological activity in stimulating the release of growth hormone. It is primarily utilized in advanced pharmaceutical research and development, particularly in the fields of endocrinology, metabolic studies, and as a critical reference standard. The peptide's unique D-amino acid sequence enhances its stability and bioavailability, making it a valuable tool for scientific investigation.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) in the development of novel growth hormone secretagogues and related therapeutics.
• Endocrinology Studies: Used in in vitro and in vivo research to investigate the mechanisms of growth hormone release and regulation.
• Metabolic Disorder Research: Employed in preclinical studies targeting conditions related to growth hormone deficiency, aging, and muscle wasting.
• Biochemical Assay Development: Serves as a critical component in the validation and calibration of bioassays and immunoassays for GHRH activity.
• Peptide Chemistry & Analog Synthesis: Provides a foundational structure for medicinal chemists to design and synthesize new peptide analogs with modified properties.

Basic Information

Product Name	D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Nle-Nh2
CAS No.	89430-34-2
Molecular Formula	C68H88N16O13
Molecular Weight	1321.5 g/mol
Synonyms	GHRH (1-29) amide, human; Growth Hormone-Releasing Factor (1-29) amide, human; hGRF(1-29)NH2; [D-Pro1, Nle27]hGRF(1-29)NH2; Sermorelin Acetate (related analog); GRF (1-29); Growth Hormone Releasing Peptide-29; GHRP-29
EINECS	Contact for details

Quality Control

Our D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Nle-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Peptide Content	≥ 80.0%
Acetate Content (HPIC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.