Description

4-Fluoro-L-Threonine is a fluorinated derivative of the essential amino acid L-threonine, characterized by the strategic substitution of a fluorine atom. This modification is crucial for its role as a key building block and metabolic probe in advanced pharmaceutical and biochemical research. It is primarily utilized by researchers and manufacturers in the life sciences sector for applications ranging from drug discovery to the study of enzyme mechanisms and protein engineering.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel fluorinated pharmaceuticals and active pharmaceutical ingredients (APIs), leveraging fluorine's ability to enhance metabolic stability and bioavailability.
• Biochemical Research: Serves as a valuable tool for studying amino acid metabolism, enzyme inhibition, and the biochemical pathways of fluorinated analogs in biological systems.
• Proteomics & Peptide Synthesis: Used in the solid-phase and solution-phase synthesis of modified peptides to investigate structure-activity relationships and create peptides with tailored properties.
• Metabolic Pathway Analysis: Acts as a tracer or an analog to probe and elucidate specific metabolic routes and enzyme functions within cells.
• Antibiotic Research: Investigated for its potential incorporation into novel antibiotic compounds, where the fluorine atom can be key to overcoming bacterial resistance.
• Academic & Industrial R&D: A fundamental reagent for universities, contract research organizations (CROs), and biotech companies engaged in cutting-edge chemical biology and medicinal chemistry projects.

Basic Information

Product Name	4-Fluoro-L-Threonine
CAS No.	89426-34-6
Molecular Formula	C4H8FNO3
Molecular Weight	137.11 g/mol
Synonyms	(2S,3S)-2-Amino-3-fluoro-4-hydroxybutanoic acid; L-4-Fluorothreonine; (2S,3S)-4-Fluorothreonine; 4-Fluoro-L-threonine; 4-Fluoro-L-threonine; 4-Fluoro-L-threonine; 4-Fluoro-L-threonine; 4-Fluoro-L-threonine
EINECS	Contact for details

Quality Control

Our 4-Fluoro-L-Threonine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Specific range provided on COA
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.