Description

Aspartic Acid, 3-(Hydroxymethyl)- is a functionalized derivative of the essential amino acid L-aspartic acid, featuring a hydroxymethyl group at the 3-position. This modification imparts unique chemical reactivity, making it a valuable chiral building block and intermediate in advanced organic synthesis. It is primarily sought by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for applications in drug discovery, peptide mimetics, and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and neurology research.
• Peptidomimetic Chemistry: Used in the design and construction of peptide analogs and mimetics to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Acts as a precursor for developing advanced herbicides, fungicides, and plant growth regulators with specific stereochemistry.
• Bioconjugation & Linker Chemistry: The hydroxymethyl group provides a handle for conjugation, useful in creating drug-linker systems for antibody-drug conjugates (ADCs) or prodrugs.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and as a standard in analytical method development.
• Specialty Polymer Monomer: Investigated for the synthesis of functionalized, biodegradable polymers with potential medical or industrial applications.

Basic Information

Product Name	Aspartic Acid, 3-(Hydroxymethyl)-
CAS No.	89417-59-4
Molecular Formula	C5H9NO5
Molecular Weight	163.13 g/mol
Synonyms	3-(Hydroxymethyl)aspartic Acid; 3-Hydroxymethyl-L-aspartic Acid; (2S,3S)-2-Amino-3-(hydroxymethyl)butanedioic acid; β-Hydroxymethylaspartic Acid; 3-Carboxymethyl-3-hydroxyalanine; HMA; A building block for Cilastatin
EINECS	Contact for details

Quality Control

Our Aspartic Acid, 3-(Hydroxymethyl)- is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure identity, strength, and purity. We provide full traceability and Certificates of Analysis (COA) are available for all shipments. Our quality commitment supports compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.