Description

4-Chloro-6-Methylthiopyrimidine is a versatile halogenated heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its bifunctional reactivity, where the chloro and methylthio groups serve as distinct handles for selective functionalization, enabling the construction of complex molecular architectures. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients, intermediates, and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various drug candidates, particularly those with pyrimidine-based cores, such as kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides, where the pyrimidine scaffold is a common structural motif.
• Material Science Research: Serves as a monomer or building block for creating novel polymers, ligands for catalysis, and organic electronic materials.
• Cross-Coupling Reactions: The chloro substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination.
• Nucleophilic Substitution: The methylthio group can be displaced or modified, offering a pathway to introduce sulfur-containing or other functional groups.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target identification.

Basic Information

Product Name	4-Chloro-6-Methylthiopyrimidine
CAS No.	89283-48-7
Molecular Formula	C5H5ClN2S
Molecular Weight	160.62 g/mol
Synonyms	4-Chloro-6-(methylthio)pyrimidine; 6-Methylthio-4-chloropyrimidine; 4-Chloro-6-methylsulfanylpyrimidine; 4-Chloro-6-methylmercaptopyrimidine; 4-Chloro-6-(methylsulfanyl)pyrimidine; 4-Chloro-6-methylthiopyrimidine; 89283-48-7; 4-Chloro-6-(methylthio)-pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-Methylthiopyrimidine is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light and moisture to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.