Description

Insulin B (22-30) is a specific, high-purity synthetic peptide fragment corresponding to amino acids 22 through 30 of the B-chain of insulin. This compound is a critical intermediate and reference standard in advanced pharmaceutical research and development, particularly for metabolic disease studies. It is essential for researchers and manufacturers in the fields of peptide synthesis, diabetes research, and the development of novel insulin analogs or biosimilar characterization.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the qualitative and quantitative analysis of insulin and its derivatives in research and quality control laboratories.
• Peptide Synthesis Intermediate: Serves as a key building block in the solid-phase or solution-phase synthesis of full-length insulin or modified insulin peptides.
• Biochemical Research: Employed in structure-activity relationship (SAR) studies to understand the function of specific regions of the insulin molecule.
• Antigen for Antibody Production: Utilized in immunology research to generate specific antibodies against this epitope of the insulin B-chain for diagnostic assay development.
• Mass Spectrometry Calibration: Acts as a precise calibrant or standard in proteomic and bioanalytical studies using HPLC-MS/MS techniques.
• Diabetes & Metabolic Disorder Studies: Applied in in vitro and ex vivo experiments to investigate insulin signaling, receptor binding, and metabolic pathways.

Basic Information

Product Name	Insulin B (22-30)
CAS No.	89270-99-5
Molecular Formula	C42H68N12O13S2
Molecular Weight	997.2 g/mol
Synonyms	Insulin B Chain (22-30); B(22-30)-Insulin; H-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-OH; Insulin B-Chain Fragment 22-30; [22-30]-Insulin B Chain; Insulin (B22-B30); B22-B30 Peptide
EINECS	Contact for details

Quality Control

Our Insulin B (22-30) CAS NO 89270-99-5 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including reversed-phase HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided to ensure compliance with research-grade standards and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.