Description

Dynorphin (3-13) is a specific, biologically active fragment of the endogenous opioid peptide dynorphin A. This compound is a critical research tool for investigating the kappa opioid receptor (KOR) system and its role in pain modulation, stress response, and neurological disorders. It is essential for pharmaceutical R&D, academic neuroscience, and biochemical research focused on developing novel therapeutic agents. The product is supplied with high purity to ensure reliable and reproducible experimental results.

Application

• Neuroscience Research: As a selective ligand for studying kappa opioid receptor (KOR) signaling pathways, neuronal excitability, and synaptic transmission.
• Pain Research: Investigation of dynorphin's complex role in spinal analgesia and the development of neuropathic pain states.
• Psychopharmacology Studies: Research into the mechanisms underlying stress, addiction, depression, and other affective disorders influenced by the KOR system.
• Biochemical Assay Development: Used as a reference standard or competing ligand in receptor binding assays (RBA), radioimmunoassays (RIA), and functional cellular assays.
• Peptide Chemistry & Drug Discovery: Serving as a starting material or pharmacophore model for the design and synthesis of novel peptide-based KOR agonists or antagonists.

Basic Information

Product Name	Dynorphin (3-13)
CAS No.	89202-80-2
Molecular Formula	C64H101N19O17
Molecular Weight	1408.6 g/mol
Synonyms	Dynorphin A (3-13); Dynorphin A Fragment 3-13; [Des-Tyr1, Des-Leu2]-Dynorphin A (1-13); H-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-OH; Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln
EINECS	Contact for details

Quality Control

Our Dynorphin (3-13) is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is subjected to comprehensive analytical characterization, including purity assessment by HPLC, identity confirmation by mass spectrometry, and amino acid analysis. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.