Description

Atriopeptin Ii Rat CAS NO 89139-54-8 is a synthetic peptide fragment corresponding to the rat isoform of Atrial Natriuretic Peptide (ANP), a key hormone involved in cardiovascular and renal homeostasis. This high-purity reference standard is essential for researchers and developers requiring precise biological activity and structural integrity in their studies. It is primarily utilized in pharmaceutical R&D, biochemical research, and diagnostic assay development focused on cardiovascular diseases, hypertension, and natriuretic peptide signaling pathways.

Application

• Biomedical Research: Used as a critical reference standard in studies investigating the physiological and pathophysiological roles of atrial natriuretic peptides.
• Drug Discovery & Development: Serves as a key reagent for screening, validating, and characterizing novel therapeutic candidates targeting ANP receptors (NPR-A).
• Diagnostic Assay Calibration: Employed for the calibration and quality control of immunoassays (e.g., ELISA) designed to measure ANP levels in biological samples.
• Signal Transduction Studies: Applied in cell-based assays to study cyclic GMP (cGMP) production and downstream signaling cascades activated by ANP binding.
• Structure-Activity Relationship (SAR) Analysis: Provides a defined molecular template for synthesizing and testing peptide analogs to understand functional domains.
• Academic & Institutional Laboratories: A fundamental tool for graduate and postdoctoral research in endocrinology, cardiology, and molecular biology.

Basic Information

Product Name	Atriopeptin Ii Rat
CAS No.	89139-54-8
Molecular Formula	C106H166N34O33S2
Molecular Weight	2477.8 g/mol
Synonyms	Atrial Natriuretic Peptide (5-27) (rat); ANP (5-27), rat; Atriopeptin II; rANP (5-27); Cardionatrin I (5-27); H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bridge: Cys7-Cys23)
EINECS	Contact for details

Quality Control

Every batch of Atriopeptin Ii Rat is manufactured and analyzed under strict quality systems. We guarantee high purity and consistent biological activity, supported by comprehensive analytical documentation. Certificates of Analysis (COA) are provided with each shipment, detailing results from HPLC, MS, and amino acid analysis to ensure compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Confirmed by in vitro cGMP induction assay (Report available)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.